CD269 Monoclonal / Biotin / REA550

Product Details

Description	Clone REA550 recognizes the mouse CD269 antigen, which is also known as B cell maturation protein BCMA. CD269 is a member of the TNF receptor superfamily. Its binding to BLyS and APRIL activates transcription factor NF-kappaB and stimulates IgM production by peripheral blood B cells. A soluble form of BCMA, which inhibits the proliferative activity of APRIL in vitro, decreases tumor cell proliferation in nude mice. CD269 has been detected in immune organs such as spleen, thymus, bone marrow, and heart, as well as at lower levels in kidney and lung and is preferentially expressed in mature B lymphocytes. \| Additional information: Clone REA550 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA550
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD269
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

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