CD103 Monoclonal / APC / REA531
Product Details
| Description | Clone REA531 recognizes the rat CD103 antigen, a type I transmembrane protein, which is also known as alphaE integrin. It associates with integrin beta7 to form the heterodimeric integrin molecule alphaEbeta7 and is a receptor for the ligand E-cadherin expressed on epithelial cells. CD103 is expressed by bone marrow–derived dendritic cells and is found on intraepithelial and peripheral lymphocytes, such as regulatory T cell subpopulations. Rat plasmacytoid dendritic cells do not express the dendritic cell–specific marker CD103. | Additional information: Clone REA531 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA531 | |
| Target Species | Rat | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD103
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 12050178 | |
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| PMID 15187127 | |
| PMID 16081812 | |
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Reviews & Ratings
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