Complement C3a R Monoclonal / PE / hC3aRZ8
Product Details
| Description | Clone hC3aRZ8 recognizes the human C3a anaphylatoxin chemotactic receptor (C3aR) antigen, a 54 kDa seven transmembrane GTP-binding-protein–coupled receptor which belongs to the rhodopsin supergene family. C3aR is expressed by various cells, including cells of hematopoietic origin such as neutrophils and monocytes, but also non-hematopoietic cells such as renal proximal tubular epithelial cells or neural cells. C3aR functions as a cell surface receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, a C-terminal 77 amino acid cleavage product of the alpha chain of C3. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3aR. After C3a binding, the C3aR signaling results in chemotaxis, granule enzyme release, and superoxide anion production. C3aR binding on T cells promotes CD4+ and CD8+ T cell activation, proliferation, differentiation, and survival, independently of TCR signals. | | |
|---|---|---|
| Conjugate | PE | |
| Clone | hC3aRZ8 | |
| Target Species | Human | |
| Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
| Size | ||
| Price | ||
| Antigen | ||
| Host | ||
| Isotype |
About Complement C3a R
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Experiment Design Tools
Panel Builders
Looking to design a Microscopy or Flow Cytometry experiment?
Validation References
| PMID 8702752 | |
|---|---|
| PMID 8765043 | |
| PMID 12871936 | |
| Additional Sources |
|
Reviews & Ratings
| Reviews |
|---|
Looking for more options?
423 Complement C3a R antibodies from over 24 suppliers available with over 66 conjugates.
