ROR gamma t Monoclonal / Unconjugated / REA278

Product Details

Description	Clone REA278 recognizes the retinoid-related orphan receptor-gamma (RORgamma) antigen and the RORgamma (t) isoform, which are ligand-dependent transcription factors that play roles in multiple physiological processes. RORgamma is expressed with highest levels in several tissues like muscle, kidney, and liver, whereas RORgamma (t) is expressed almost exclusively in immature CD4+CD8+ double-positive thymocytes. RORgamma is the possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivator recruitment. It is essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. RORgamma (t) negatively regulates expression of Fas ligand and IL-2 production in T cells. It also binds to the TEA promoter and may be part of the pre-TCR activation cascade leading to the maturation of alpha/beta T cells and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus. \| Additional information: Clone REA278 displays negligible binding to Fc receptors. \|
Conjugate	Unconjugated
Clone	REA278
Target Species	Human, Mouse
Applications	Mass Cytometry
Supplier	Miltenyi Biotec
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