IL-12 (p70) Monoclonal / Unconjugated / REA123

Product Details

Description	Interleukin-12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages and by dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both NK and T cells, playing an essential role in the interaction between innate and adaptive immunity. It induces the production of IFN-gamma alone or in synergy with IL-2, acts as a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Tʜ1)-specific immune responses by promoting the differentiation of CD4+ cells towards a Tʜ1 phenotype while inhibiting the production of Tʜ2 cells. Clone REA123 reacts with the biologically active form of human IL-12 p70 heterodimer, but not with the p40 monomer or homodimer. \| Additional information: Clone REA123 displays negligible binding to Fc receptors. \|
Conjugate	Unconjugated
Clone	REA123
Target Species	Human
Applications	Mass Cytometry
Supplier	Miltenyi Biotec
	Catalog #	Sign in to view product details, citations, and spectra
	Size
	Price
	Antigen
	Host
	Isotype