STAT1 (pS727) Monoclonal / APC / REA525

Product Details

Description	Clone REA525 recognizes the signal transducer and activator of transcription 1 (STAT1) antigen phosphorylated at serine 727 (pS727). STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. STAT1 is an essential transcription factor for macrophage activation by IFN-gamma and requires phosphorylation of the C-terminal pS727 for transcriptional activity. It forms homodimers or heterodimers with STAT3 that bind to the IFN-gamma activated sequence promoter element. In response to either IFN-alpha or IFN-beta stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes. \| Additional information: Clone REA525 displays negligible binding to Fc receptors.
Conjugate	APC
Clone	REA525
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
	Catalog #	Sign in to view product details, citations, and spectra
	Size
	Price
	Antigen
	Host
	Isotype

About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

Experiment Design Tools