CD185 Monoclonal / PE-Vio615 / REA215
Product Details
| Description | Clone REA215 recognizes murine CD185, which is a 42 kDa multipass chemokine receptor, also known as CXCR5 or burkitt lymphoma receptor-1 (BLR). Expression of CD185 is found on mature recirculating B cells, a small subset of CD4+ and CD8+ T cells, and skin-derived migratory dendritic cells. CXCR5 recognizes B cell–attracting chemokine 1 (BCA-1)/ CXCL13 as ligand, which is a homeostatic chemokine, constitutively secreted by stromal cells in B cell areas of secondary lymphoid tissues (follicles). CXCR5 is involved in recruitment of circulating naive B cells to follicles and trafficking and homing of B1 B cells. Mice lacking CXCR5 gene display defective primary follicles and germinal centers formation in the spleen and Peyer patches, and lack inguinal lymph nodes. | Additional information: Clone REA215 displays negligible binding to Fc receptors. | | |
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| Conjugate | PE-Vio615 | |
| Clone | REA215 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About CD185
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
About PE-Vio615
PE-Vio®615 from Miltenyi Biotec has an excitation peak at 565 nm and an emission peak at 619 nm. It is spectrally similar to PE-eFluor™ 610, PE-Dazzle 594 and PE-CF®594
PE-Vio®615 from Miltenyi Biotec has an excitation peak at 565 nm and an emission peak at 619 nm. It is spectrally similar to PE-eFluor™ 610, PE-Dazzle 594 and PE-CF®594
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Validation References
| PMID 16301613 | |
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| PMID 19234155 | |
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