CCL18 Monoclonal / APC / REA487

Product Details

Description	Clone REA487 recognizes the C-C motif chemokine 18 (CCL18) antigen, a secreted protein also known as macrophage inflammatory protein 4 (MIP-4) or dendritic cell chemokine 1 (DC-CK1). CCL18 is a cytokine belonging to the members of the CC subfamily of chemokines. Chemokines are chemotactic cytokines that guide the directed migration of leukocytes in the steady-state and in inflammation through a subfamily of seven-transmembrane spanning G protein–coupled receptors. CCL18 is secreted primarily by cells of the myeloid lineage and has been identified in alveolar macrophages, tolerogenic dendritic cells, alternatively activated macrophages (AAMs), and keratinocytes. In macrophages, CCL18 is induced by the Tʜ2 cytokines IL-4 and IL-13, which program macrophages to differentiate into AAMs. CCL18 is highly expressed in many human chronic inflammatory diseases, which include pulmonary fibrosis and certain cancers, and a wide range of allergic diseases. In some diseases, the level of circulating CCL18 has been demonstrated to be a biomarker for disease activity and outcome. \| Additional information: Clone REA487 displays negligible binding to Fc receptors.
Conjugate	APC
Clone	REA487
Target Species	Human
Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Supplier	Miltenyi Biotec
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About CCL18
Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and ubiquitin protein ligase binding activity. Involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Located in cytosol. Part of cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

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