TCR V beta 23 Monoclonal / PE / REA497

Product Details

Description	Clone REA497 recognizes the human variable beta 23 subunit of the alphabeta T cell receptor (TCR Vbeta23). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The alpha and beta TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vbeta23 is a variant of the TCR beta chain. alphabeta T cells express a diverse alphabeta TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell–mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of alphabeta T cell–mediated immunity and underpins MHC restriction. \| Additional information: Clone REA497 displays negligible binding to Fc receptors.
Conjugate	PE
Clone	REA497
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.

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