CD132 Monoclonal / Biotin / REA313

Product Details

Description	Clone REA313 recognizes the human CD132 antigen, a 65–70 kDa single-pass type I membrane protein also known as common gamma chain, which is shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. CD132 is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. The most common form of severe combined immune deficiency in humans, with lack of circulating T cells, a normal or increased number of B lymphocytes, and an X-linked pattern of inheritance (XSCID) has been shown to be due to defects of the CD132 gene. \| Additional information: Clone REA313 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA313
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About CD132
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

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