MSR1 Monoclonal / Biotin / REA460
Product Details
| Description | Clone REA460 recognizes the human CD204 antigen, a single-pass type II membrane protein which is also known as macrophage scavenger receptor type I (MSR1) or scavenger receptor class A (SR-A). CD204 is one of the major scavenger receptors expressed on human macrophages and dendritic cells. It plays roles in lipid metabolism, atherogenesis, and a number of metabolic processes. Recent evidence also points to important roles for CD204 in inflammation, innate immunity, host defense, sepsis, and ischemic injury. CD204 inhibits macrophage activation by scavenging ligands of toll-like receptor 4 and suppresses inflammatory cytokine production. Immunohistochemical studies in gliomas, pancreatic cancer, kidney cancer, esophageal cancer, and lung cancer have shown that CD204 expression in tumor tissues is closely restricted to tumor-associated macrophages and that high expression of CD204 is associated with a high malignant potential of tumor cells. | Additional information: Clone REA460 displays negligible binding to Fc receptors. | |
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| Conjugate | Biotin | |
| Clone | REA460 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About MSR1
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
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Validation References
| PMID 2251254 | |
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| PMID 21914786 | |
| PMID 24942947 | |
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