TCR V alpha 11.1/11.2 Monoclonal / Biotin / REA464

Product Details

Description	Clone REA464 recognizes the mouse V alpha 11.1 and 11.2 T cell receptor (TCR Valpha11.1, 11.2) of mice having the b (e.g., C57BL/6) and d (e.g., DBA/1, DBA/2, NZW) haplotypes, but not with the strains having the a (Balb/c) or c (e.g., SJL, NOD) haplotype. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable alpha and beta chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Valpha elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Valpha elements interact preferentially with conserved regions of class I or class II molecules. \| Additional information: Clone REA464 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA464
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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