Podoplanin Monoclonal / APC / REA446
Product Details
| Description | Clone REA446 recognizes the human podoplanin antigen, a 38–44 kDa mucin-type transmembrane protein which is also known as E11, GP38, OTS8, PA2.26, T1A, or aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis, and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen four days postnatally. In adults, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. | Additional information: Clone REA446 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA446 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Podoplanin
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 10393083 | |
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| PMID 22988448 | |
| PMID 23995678 | |
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