CD46 Monoclonal / VioBlue / REA312
Product Details
| Description | Clone REA312 recognizes the human CD46 antigen, a type I transmembrane glycoprotein, which is also known as the membrane cofactor protein (MCP). At least fourteen different transcript variants encoding different isoforms have been found for CD46. It is expressed by a broad range of tissues including leukocytes, platelets, epithelial cells, and fibroblasts, but not by erythrocytes. CD46 acts as a co-factor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It is involved in the fusion of the spermatozoa with the oocyte during fertilization. Additionally, CD46 functions as a receptor for measles virus, human herpesvirus, and human adenovirus. It is a potent costimulator for the induction of interferon-gamma secreting effector T helper type 1 cells and their subsequent switch into interleukin 10 producing regulatory T cells. | Additional information: Clone REA312 displays negligible binding to Fc receptors. | | |
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| Conjugate | VioBlue | |
| Clone | REA312 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD46
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
About VioBlue
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).
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Validation References
| PMID 2050389 | |
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| PMID 8402913 | |
| PMID 23086448 | |
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