Myosin heavy chain Monoclonal / VioBlue / REA399

Product Details

Description	Clone REA399 recognizes the human, mouse, and rat cardiac isoform of the myosin heavy chain (MHC) antigen. Myosin forms cross-bridges with actin in cardiac, smooth, and skeletal muscle, and cyclic cross-bridge activity is the basis for muscular contraction. It is a hexamer composed of two heavy chains, each of which contains an actin-binding site and an ATP hydrolysis site, and four light chains. Isoforms of each myosin subunit are expressed in cardiac, skeletal, and smooth muscle, and many are associated with distinct contractile properties in the muscles or single muscle fibers in which they are expressed. In cardiac muscle, two MHC isoforms, termed alpha-MHC and beta-MHC, are present. alpha-MHC is associated with higher actomyosin ATPase activity compared with beta-MHC. The relative amounts of the two isoforms may vary, with the ratio being a function of the hormonal status, the developmental stage, the animal, or the particular region of the heart. \| Additional information: Clone REA399 displays negligible binding to Fc receptors.
Conjugate	VioBlue
Clone	REA399
Target Species	Human, Mouse, Rat
Applications	FC
Supplier	Miltenyi Biotec
	Catalog #	Sign in to view product details, citations, and spectra
	Size
	Price
	Antigen
	Host
	Isotype

About VioBlue
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).

Experiment Design Tools