ATP7b / Biotin / Polyclonal

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Description ATP7b Polyclonal Antibody, Biotin conjugate. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver.ICC 1:10-1:2000, WB 1:1000, IF 1:10-1:2000
Conjugate Biotin
Clone Polyclonal
Target Species Human, Rat
Applications IF, ICC, WB
Supplier Thermo Fisher Scientific
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About ATP7b
This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019]
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373 ATP7b antibodies from over 19 suppliers available with over 52 conjugates.

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