HACE1 / Biotin / 8D3
Product Details
| Description | Hace 1 Monoclonal Antibody, Biotin conjugate (8D3). E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.WB Assay Dependent, IF Assay Dependent, IHC (P) Assay Dependent, ELISA Assay Dependent - - | |
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| Conjugate | Biotin | |
| Clone | 8D3 | |
| Target Species | Human | |
| Applications | ELISA, IF, WB, IHC | |
| Supplier | Thermo Fisher Scientific | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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160 HACE1 antibodies from over 16 suppliers available with over 16 conjugates.
