HIF-2 alpha / Biotin / ep190b

Product Details

Description	HIF-2 alpha Monoclonal Antibody, Biotin conjugate (ep190b). Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1 alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.IHC (P) 1:150-1:300, WB 1:500
Conjugate	Biotin
Clone	ep190b
Target Species	Hamster, Human, Mouse, Rat
Applications	WB
Supplier	Thermo Fisher Scientific
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About HIF-2 alpha
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009]

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