Complement Factor B / Biotin / 10C5
Product Details
| Description | Properdin Monoclonal Antibody, Biotin conjugate (10C5). Properdin in plasma is a mixture of cyclic dimers, trimers and tetramers. The molecular weight of the glycosylatedmonomer is 53 kDa. Properdin is a regulator protein of the alternative complement pathway. It stabilizes the C3convertase excerting its effect by binding to C3b in the C3bBb complex and thereby inhibiting cleavage of C3bby factor I and increasing the affinity for factor B. Serum concentration is approximately 25 µg/ml.ELISA Assay dependent, WB Assay Dependent - - | |
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| Conjugate | Biotin | |
| Clone | 10C5 | |
| Target Species | Human | |
| Applications | ELISA, WB | |
| Supplier | Thermo Fisher Scientific | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Complement Factor B
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
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