About CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

About StarBright Blue 675
StarBright Blue 675 (SBB675) Dye is a very bright, 488 nm laser excitable dye with a unique narrow excitation and emission profile and is suitable for conventional and full spectrum flow cytometry. It is brighter than other 488 nm laser excitable dyes such as PerCP-Cy5.5 (and PerCP) and BB700 and PE-Cy5 when excited by the 488 nm laser. As it is not a traditional tandem dye, SBB675 does not have issues around tandem breakdown and changes to staining over time. It exhibits reduced excitation by the 561 nm laser compared to PE tandem dyes. SBB675 provides more choice and flexibility when building multicolor panels incorporating the 488 nm laser.