About CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

About MagDot 640
MagDot 640 is a nanoparticle optimally excited from 320 nm to 405 nm with an emission peak at 640 nm. This dye is part of Core Quantum Technologies' MagDot product line. Each MagDot consists of both quantum dots and magnetic iron oxides in the same particle. This allows for magnetic separation/ enrichment of targeted cells for downstream flow cytometric analysis or an application using electron microscopy.