About CTLA-4
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

About RealYellow 586
BD Horizon RealYellow 586 (RY586) is a bright, yellow emitting dye used in flow cytometry. This fluorophore is excited optimally by the 561 laser and is similar in its emission properties to PE, but interestingly, RY586 shows minimal cross-laser excitation with the 488 laser and can be used in spectral flow cytometry panels concurrently with PE (as stated by supplier).