GITR Ligand / Vio Bright V423 / REA841

Product Details

Description	Clone REA841 recognizes the human GITRL, also known as the ligand for GITR (glucocorticoid-induced TNF receptor superfamily-related protein) and also called AITR (activation-inducible TNF receptor superfamily-related protein). GITRL, a type II membrane protein and a member of the TNF superfamily, is highly expressed in small intestine, ovary, testis, kidney, and endothelial cells. GITRL is not found in resting or stimulated T cells, B cells, or peripheral blood mononuclear cells (PBMCs). After stimulation by bacterial lipopolysaccharides (LPS), GITRL is upregulated. GITR and GITRL might play an important role for interactions between activated T lymphocytes and endothelial cells. Furthermore, overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses. \| Additional information: Clone REA841 displays negligible binding to Fc receptors.
Conjugate	Vio Bright V423
Clone	REA841
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About Vio Bright V423
Vio® Bright V423 is a very bright Violet emitting synthetic fluorophore used in flow cytometry. The excitation and emission peaks are 399 nm and 420 nm, respectively, which means that this dye is optimally excited by the 405 nm Violet laser while the emission light is collected by a 450/50 bandpass filter.

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