MHC Qa1b / Biotin / 6A8.6F10.1A6

Product Details

Description	Clone 6A8.6F10.1A6 recognizes murine QA-1B, a 48 kDa non-classical MHC class Ib molecule encoded by the H2-T23 gene on chromosome 17. QA-1 associates with beta2-microglobulin and its surface expression is found on activated hematopoietic cells, T cells, dendritic cells (DCs), macrophages, and neurons. Murine QA-1 presents a nine amino acid peptide called QA-1 determinant modifier (Qdm), peptides from proteins associated with infectious or inflammatory response, and a heat shock protein 60 (HSP60)–derived peptide (in the absence of Qdm) to immunoregulatory CD8+ T cells. QA-1B also serves as a ligand for C-type lectin CD94/NKG2 receptors and depending on the NKG2 family member involved, this interaction can result in an inhibitory or an activating signal.
Conjugate	Biotin
Clone	6A8.6F10.1A6
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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