Fc epsilon R1 alpha / VioBright 515 / CRA1
Product Details
| Description | Clone CRA1 detects the alpha subunit of the human high-affinity Fc receptor for IgE. The receptor is composed of one alpha-, one beta-, and two disulphide-linked gamma-chains, of which the alpha subunit binds IgE1. FcepsilonRIalpha is expressed on mast and basophil cells, is upregulated in the presence of IgE, and is found on a subset of blood dendritic cells. CRA1 does not inhibit the binding of IgE it induces mast cell activation followed by a histamine release. The FcepsilonRI complex plays an important role in triggering IgE-mediated allergic reactions. | |
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| Conjugate | VioBright 515 | |
| Clone | CRA1 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About Fc epsilon R1 alpha
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
About VioBright 515
Vio®Bright® B515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is comparable to BB515 in flow cytometry.
Vio®Bright® B515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is comparable to BB515 in flow cytometry.
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