Midkine / Biotin /

Product Details

Description	Midkine (MK, MDK), or Neurite Growth-promoting Factor 2, is a basic heparin-binding growth factor1 , a member of the NEGF family founded by Pleiotrophin. It is a non-glycosylated protein. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair. MK is capable of exerting activities such as cell proliferation, cell migration, angiogenesis and fibrinolysis. MK application could be a new therapeutic strategy for the treatment of ischemic heart failure.2
Conjugate	Biotin
Clone
Target Species	Human
Applications	WB
Supplier	Leinco
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About Midkine
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

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