IL-1 alpha / Unconjugated /
Product Details
| Description | IL-1R1 is an 80 kD transmembrane glycoprotein and a member of the Ig superfamily. IL-1 binds both IL-1R1 and IL-1R2. The ligands IL-1alpha and IL-1beta only commence when binding IL-1R1 because IL-1R2 acts as a decoy receptor and competitively antagonizes the binding of IL-1alpha and IL-1beta, thereby reducing their biological effects. Binding of the ligands to IL-1R1 is enhanced by an accessory protein, IL-1R-AcP. IL-1alpha can exist as either a 31 kD precursor or an 18 kD mature form. IL-1alpha is a proinflammatory cell-associated cytokine and IL-1beta is a 17.5 kD proinflammatory secreted cytokine. Both IL-1alpha and IL-1beta bind to the same receptor and have similar properties that include stimulation of thymocyte proliferation via IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Furthermore, IL-1beta mediates a variety of immune and inflammatory responses. IL-1beta is a major cause of severe inflammation in the mouse model of Crohn’s Disease, which makes IL-1beta an important target for this disease. | |
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| Conjugate | Unconjugated | |
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| Target Species | Mouse | |
| Applications | IHC FF, Block/Neutralize, WB | |
| Supplier | Leinco | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About IL-1 alpha
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
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1261 IL-1 alpha antibodies from over 30 suppliers available with over 38 conjugates.
