CD121a / DyLight 594 / JAMA-147

Product Details

Description	IL-1R1 is an 80 kD transmembrane glycoprotein and a member of the Ig superfamily. IL-1 binds both IL-1R1 and IL-1R2. The ligands IL-1alpha and IL-1beta only commence when binding IL-1R1 because IL-1R2 acts as a decoy receptor and competitively antagonizes the binding of IL-1alpha and IL-1beta, thereby reducing their biological effects. Binding of the ligands to IL-1R1 is enhanced by an accessory protein, IL-1R-AcP. IL-1alpha can exist as either a 31 kD precursor or an 18 kD mature form. IL-1alpha is a proinflammatory cell-associated cytokine and IL-1beta is a 17.5 kD proinflammatory secreted cytokine. Both IL-1alpha and IL-1beta bind to the same receptor and have similar properties that include stimulation of thymocyte proliferation via IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. Furthermore, IL-1beta mediates a variety of immune and inflammatory responses. IL-1beta is a major cause of severe inflammation in the mouse model of Crohn’s Disease, which makes IL-1beta an important target for this disease.
Conjugate	DyLight 594
Clone	JAMA-147
Target Species	Mouse
Applications	FC
Supplier	Leinco
	Catalog #	Sign in to view product details, citations, and spectra
	Size
	Price
	Antigen
	Host
	Isotype

About CD121a
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

About DyLight 594
DyLight™ 594 has an excitation peak at 593 nm and an emission peak at 618 nm and is spectrally similar to Alexa Fluor™ 594 and Texas Red. DyLight™ 594 is most commonly used in flow cytometery and fluorescence microscopy applications.

Experiment Design Tools