IFNGR1 / DyLight 594 / GIR-208

Product Details

Description	IFNgamma Ralpha, or IFNgamma R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNgamma Receptor consists of alpha and ß chains and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction which induces tyrosine phosphorylation of IFN-gamma Ralpha leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription.
Conjugate	DyLight 594
Clone	GIR-208
Target Species	Human
Applications	FC
Supplier	Leinco
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About IFNGR1
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

About DyLight 594
DyLight™ 594 has an excitation peak at 593 nm and an emission peak at 618 nm and is spectrally similar to Alexa Fluor™ 594 and Texas Red. DyLight™ 594 is most commonly used in flow cytometery and fluorescence microscopy applications.

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