DAD1 / Unconjugated /

Product Details

Description	Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death1, a process important for normal organism development and tissue homeostasis.2 DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity.3,4 Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death.5,6 Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas7, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
Conjugate	Unconjugated
Clone
Target Species	Human
Applications	IHC FFPE, WB
Supplier	Leinco
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About DAD1
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

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