TCR V gamma 9 / APC-Vio770 / REA470
Product Details
| Description | Clone REA470 recognizes the human variable gamma 9 subunit of the gamma/delta T cell receptor (TCR Vgamma9). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The gamma and delta TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. gammadelta T cells represent unconventional lymphocytes that share characteristics of natural killer (NK) cells and T cells and often express regulatory NK receptors, thereby linking innate and adaptive immunity. Upon cross-linking CD94/NKG2A, antigenic activation of gammadelta T cells is down-modulated by inhibiting cell proliferation, cytokine production, and cytotoxicity. gammadelta T cells can detect target cells with patterns of MHC class I expression altered as a result of tumor transformation or viral infection, thus endowing them with a role in immunosurveillance originally attributed to NK cells only. Vgamma9/Vdelta2 T cells comprise the majority of peripheral human gammadelta T cells and are capable of responding to the microbial metabolite HMB-PP. | Additional information: Clone REA470 displays negligible binding to Fc receptors. | |
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| Conjugate | APC-Vio770 | |
| Clone | REA470 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About TCR V gamma 9
Predicted to be involved in adaptive immune response and innate immune response. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Predicted to be involved in adaptive immune response and innate immune response. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
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84 TCR V gamma 9 antibodies from over 9 suppliers available with over 33 conjugates.
