Siglec-5/Siglec-14 / APC-Vio770 / REA393

Product Details

Description	Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5. \| Additional information: Clone REA393 displays negligible binding to Fc receptors.
Conjugate	APC-Vio770
Clone	REA393
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

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