CD158 / Vio Bright R720 / REA1042

Product Details

Description	Clone REA1042 recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype on human and non-human primate cells. It recognizes all KIRs bearing two extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). KIRs are expressed on CD56dimCD16+ natural killer (NK) cells and a subset of CD8+ T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs (KIR2DL or KIR3DL) and short-tailed activating KIRs (KIR2DS or KIR3DS). \| Additional information: Clone REA1042 displays negligible binding to Fc receptors.
Conjugate	Vio Bright R720
Clone	REA1042
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About Vio Bright R720
Vio® Bright R720 and Vio® R720 have an excitation peak at 695 nm and an emission peak at 720 nm, which means that these dyes are optimally excited by the 640 nm red laser while the emitted light is collected by the channel with a 725/40 bandpass filter. Miltenyi Biotec's proprietary multimerization technology allows for Vio® Bright R720 to be nearly twice the brightness of Vio® R720, so this choice of fluorophore offers flexibility in your panel design in flow cytometry. Spectrally, Vio® Bright R720 is comparable to R700 from BD Biosciences.

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