CD85d / Unconjugated / REA184

Product Details

Description	Clone REA184 recognizes CD85d, also known as immunoglobulin-like transcript 4 (ILT4) or leukocyte Ig-like receptor 2 (LIR2). CD85d is an inhibitory immunoreceptor, expressed mainly on myelomonocytic lineage cells. \| CD85d has four tandem Ig-like extracellular domains and three immunoreceptor tyrosine-based inhibitory receptor motifs in its cytoplasmic tails, which recruit the tyrosine phosphatase Src homology 2 domain containing phosphatase 1 (SHP-1). It has been shown that CD85d interacts with HLA-A, -B, -G1, and -E molecules as ligands. HLA-G expression is restricted to trophoblasts and thus interaction of CD85d with HLA-G is suggested to inhibit placental leukocytes, contributing to maternal tolerance of the fetal semiallograft. \| Additional information: Clone REA184 displays negligible binding to Fc receptors. \|
Conjugate	Unconjugated
Clone	REA184
Target Species	Human
Applications	Mass Cytometry
Supplier	Miltenyi Biotec
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