CD49d / Vio Bright V423 / REA545
Product Details
| Description | Clone REA545 recognizes the human CD49d antigen, which belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD49d, also known as the alpha4 integrin chain or VLA-4alpha chain, is a cell adhesion protein that is directly involved in mononuclear leukocyte trafficking. Dimerized with beta7 integrin, the resulting alpha4beta7 integrin binds VCAM-1 (CD106), MAdCAM-1, and fibronectin to facilitate the rolling of leukocytes along vascular epithelium. In T cells, on ligation of MAdCAM-1, alpha4beta7 integrin also provides costimulation of T cell receptor/CD3–mediated signaling. | CD49d is expressed on most mononuclear leukocytes, both in circulation or in lymphoid or other tissues, as well as on eosinophils and basophils. | Additional information: Clone REA545 displays negligible binding to Fc receptors. | |
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| Conjugate | Vio Bright V423 | |
| Clone | REA545 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About CD49d
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
About Vio Bright V423
Vio® Bright V423 is a very bright Violet emitting synthetic fluorophore used in flow cytometry. The excitation and emission peaks are 399 nm and 420 nm, respectively, which means that this dye is optimally excited by the 405 nm Violet laser while the emission light is collected by a 450/50 bandpass filter.
Vio® Bright V423 is a very bright Violet emitting synthetic fluorophore used in flow cytometry. The excitation and emission peaks are 399 nm and 420 nm, respectively, which means that this dye is optimally excited by the 405 nm Violet laser while the emission light is collected by a 450/50 bandpass filter.
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