CD126 / PE-Vio770 / REA291

Product Details

Description	Clone REA291 recognizes the CD126 antigen, a type I cytokine receptor also known as interleukin 6 receptor subunit alpha (IL-6Ralpha) or membrane glycoprotein 80 (gp80). CD126 associates with the IL-6 receptor beta chain (CD130 or gp130) resulting in the formation of a functional high affinity IL-6 receptor (IL-6R) complex. It is also shared by many other receptors like leukemia inhibitory factor (LIF), ciliary neurotropic factor (CNTF), oncostatin M (OSM), IL-11, and cardiotropin 1 (CT-1). CD126 (IL-6Ralpha) is highly expressed on activated and EBV-transformed B cells, plasma cells, and myeloma cells. Lower expression levels are detected on T cells, monocytes, granulocytes, hepatocytes, epithelial cells, fibroblasts, and neural cells. Interleukin 6 (IL-6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 also exists in human serum. Dysregulated production of IL-6 and the IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. \| Additional information: Clone REA291 displays negligible binding to Fc receptors. \|
Conjugate	PE-Vio770
Clone	REA291
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

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