Phosphotyrosine / ATTO 488 / G104

Product Details
Description Mouse monoclonal to Phosphotyrosine (ATTO-488). Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a proteins activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time. Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (4-6). In particular, the phosphorylation of tyrosine is considered one of the key steps in signal transduction and regulation of enzymatic activity. Phosphotyrosine can be detected through specific antibodies, and are helpful in facilitating the identification of tyrosine kinase substrates..
Conjugate ATTO 488
Clone G104
Target Species All Species
Applications ICC, WB, IP, IHC
Supplier Biorbyt
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About ATTO 488
ATTO 488 is from ATTO-Tec Gmbh has an excitation peak at 501 nm and an emission peak at 523 nm.
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454 Phosphotyrosine antibodies from over 31 suppliers available with over 55 conjugates.

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