About CD4
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]

About PE-Fire 810
Along with APC/Fire 810™, PE/Fire™ 810 expands the range of spectral detection further than any of our previous fluorophores, emitting even beyond the range of PE/Cyanine7. Optimized for spectral unmixing cytometers, PE/Fire™ 810 is excited by the blue and yellow/green lasers and can utilized for nearly any antigen since it has little spectral overlap with other fluorophores. While we have released several PE tandem options, our data below shows PE/Fire™ 810 can be unmixed from them in a multicolor panel.