Urokinase / Biotin /

Product Details
Description Urokinase Plasminogen Activator (PLAU, plasminogen activator, urokinase, HGNC:9052, ATF, UPA, URK, u-PA , U-plasminogen activator, antagonist of uPA, plasminogen activator, urinary, urokinase plasminogen activator, urokinase-type plasminogen activator amino-terminal fragment, urokinase-type plasminogen activator precursor) (Biotin) Pab
Conjugate Biotin
Clone
Target Species Mouse
Applications ELISA, WB
Supplier US Biological
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About Urokinase
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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