UPF1 / HRP /

Product Details
Description UPF1 (UP Frameshift 1, FLJ43809, FLJ46894, HUPF1, KIAA0221, NORF1, Regulator of Nonsense Transcripts 1, RENT1, pNORF1) (HRP) Pab
Conjugate HRP
Clone
Target Species Human
Applications IF, WB, IHC
Supplier US Biological
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About UPF1
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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216 UPF1 antibodies from over 21 suppliers available with over 27 conjugates.

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