Jagged 2 Monoclonal / Biotin / HMJ2-1
Product Details
| Description | The HMJ2-1 monoclonal antibody recognizes mouse Jagged2, a transmembrane protein also called JAG2. Jagged 2 is one of five Notch receptor ligands expressed on thymic lymphoid and stromal cells, splenic DCs and macrophages but not on B cells. It is reported that Jagged 2 promotes metastasis in lung by increasing the expression of GATA binding factors. | |
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| Conjugate | Biotin | |
| Clone | HMJ2-1 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Jagged 2
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Validation References
| PMID 18381350 | |
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| PMID 19181931 | |
| PMID 21403400 | |
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