TDG / Biotin /

Product Details
Description TDG (G/T Mismatch-specific Thymine DNA Glycosylase, Thymine-DNA Glycosylase, hTDG) (Biotin) Pab
Conjugate Biotin
Clone
Target Species Human
Applications WB
Supplier US Biological
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About TDG
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
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219 TDG antibodies from over 17 suppliers available with over 33 conjugates.

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