CD3 epsilon Monoclonal / Unconjugated / 145-2C11

Product Details

Description	Clone 145-2C11 specifically recognizes the epsilon subunit of the mouse CD3 antigen. CD3 is a 20 kDa transmembrane protein and is part of the TCR complex. Along with the gamma and delta subunits of CD3, the epsilon chain is required for proper assembly and expression of the TCR complex. CD3epsilon is expressed on thymocytes, mature T lymphocytes, and NKT cells. \| Antibody clone 145-2C11 can be used for T cell activation and expansion.
Conjugate	Unconjugated
Clone	145-2C11
Target Species	Mouse
Applications	Functional
Supplier	Miltenyi Biotec
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About CD3 epsilon
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

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