CD81 Monoclonal / Biotin / EAT2

Product Details
Description CD81 is widely expressed and is involved in a variety of biological processes. In the brain it is expressed on astrocytes, oligodendrocytes, microglia, and endothelial cells. The CD81 antigen is a 26 kDa cell surface glycoprotein, also known as TAPA-1, and a member of the tetraspanin family, characterised by the presence of four hydrophobic domains. CD81 is known to complex with integrins, and mediates signal transduction events in the regulation of muscle cell fusion, myotube maintenance, signal transduction, cell development, activation, growth, and motility. The CD81 gene is localized in the tumor suppressor gene region and thus it is a candidate gene for malignancies.
Conjugate Biotin
Clone EAT2
Target Species Mouse, Rat
Applications FC
Supplier Miltenyi Biotec
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About CD81
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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Validation References
PMID 9597125
PMID 11273649
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