CD85g Monoclonal / Biotin / REA100

Product Details

Description	The clone REA100 recognizes human CD85g, also known as immunoglobulin-like transcript 7 (ILT7), a cell surface receptor which is specifically expressed on human plasmacytoid dendritic cells (PDCs). ILT7 associates with FcepsilonR1gamma chain through positively charged arginine residue located in the transmembrane domain to form a receptor complex. Cross-linking of ILT7 results in FcepsilonR1gamma-dependent activation of an ITAM-mediated signaling pathway, which negatively influences TLR7/9 induced type I IFN production. Cross-linking of ILT7 by REA100 monoclonal antibodies inhibits type I IFN production in human PDCs. \| Additional information: Clone REA100 display negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA100
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About CD85g
This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

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