HLA Class I Bw6 Monoclonal / VioGreen / REA143
Product Details
| Description | Clone REA143 recognizes HLA Bw6, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane alpha heavy chain and soluble beta2 microglobulin protein. The extracellular region of the heavy chain further consists of 3 domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Downregulation of HLA class I Bw6 allele has been reported in leukemic patients where it is suggested that via this downregulation, leukemic cells may circumvent attack by CTLs. | Additional information: Clone REA143 displays negligible binding to Fc receptors. | |
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| Conjugate | VioGreen | |
| Clone | REA143 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About VioGreen
Vio®Green from Miltenyi has an excitation peak at 388 nm and an emission peak at 520 nm.
Vio®Green from Miltenyi has an excitation peak at 388 nm and an emission peak at 520 nm.
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Validation References
| PMID 14511229 | |
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| PMID 15070694 | |
| PMID 27530248 | |
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Reviews & Ratings
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25 HLA Class I Bw6 antibodies available with over 13 conjugates.
