CD51 Monoclonal / PE / REA181

Product Details
Description Clone REA181 recognizes CD51, also known as alphaV integrin, which is a 140 KDa single pass type I membrane protein. CD51 forms heterodimers with beta1, beta3, beta5, or beta6 inetgrins and serves as a receptor for diverse extra cellular matrix proteins such as fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, laminin, and matrix metalloproteinase-2. | Additional information: Clone REA181 displays negligible binding to Fc receptors. |
Conjugate PE
Clone REA181
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Supplier Miltenyi Biotec
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About CD51
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
PMID 8165561
PMID 9547294
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