CD72 Monoclonal / PE / REA231

Product Details
Description Clone REA231 recognizes CD72, a 45 kDa type II membrane protein with a C-type lectin-like domain. Expression of CD72 is found on most B-lineage cells, follicular dendritic cells, mast cells, and liver Kupffer cells. CD72 is recognized as negative regulator of B cell receptor (BCR) signaling, as well as regulating mast cell growth and differentiation via KIT activation. The inhibitory role of CD72 is exerted via the ITIM sequence in the cytoplasmic tail. | Additional information: Clone REA231 displays negligible binding to Fc receptors. |
Conjugate PE
Clone REA231
Target Species Human
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Supplier Miltenyi Biotec
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About CD72
Predicted to enable signaling receptor binding activity. Predicted to be involved in cell adhesion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
PMID 16621999
PMID 20100931
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502 CD72 antibodies from over 27 suppliers available with over 64 conjugates.

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