CD104 Monoclonal / APC-Vio770 / REA236

Product Details
Description Clone REA236 recognizes CD104, which is also known as integrin beta4. Integrins are a family of type I transmembrane heterodimeric glycoprotein receptors and exist as non-covalently bound alpha and beta subunits. CD104 interacts with alpha6 integrin and serves as receptor for laminin and component of hemidesmosomes. Expression of alpha6beta4 integrin is found in the basal aspect of stratified epithelia such as epidermis, stratified squamous epithelium of squamous mucosa, urothelium, and certain tumor cells. | Additional information: Clone REA236 displays negligible binding to Fc receptors. |
Conjugate APC-Vio770
Clone REA236
Target Species Human
Applications FC
Supplier Miltenyi Biotec
Catalog # Sign in to view product details, citations, and spectra
Size
Price
Antigen
Host
Isotype
About CD104
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
Experiment Design Tools
Panel Builders

Looking to design a Microscopy or Flow Cytometry experiment?

Validation References
PMID 7803849
PMID 8165561
Additional
Sources
Reviews & Ratings
Looking for more options?

712 CD104 antibodies from over 31 suppliers available with over 77 conjugates.

Supplier Page
 Compare