CD270 Monoclonal / APC / REA247
Product Details
| Description | Clone REA247 recognizes CD270, which is also known as HVEM and derives its name based on the ability of types 1 and 2 herpesvirus gD to bind to it for entry into the cell. CD270 is a type 1 transmembrane protein with a predicted molecular weight of 30 kDa and is a member of the TNFR superfamily. CD270 transmits both activating and inhibitory signals for, e.g., interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells. Expression of CD270 is widely distributed and is found on hematopoietic cells such as dendritic cells, Tregs, monocytes, neutrophils, NK cells, B cells, and T cells, as well as on non-hematopoietic cells. | Additional information: Clone REA247 displays negligible binding to Fc receptors. | | |
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| Conjugate | APC | |
| Clone | REA247 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About CD270
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 19760072 | |
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| PMID 22445654 | |
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